Diagnostic Utility of Various Techniques In Bone Tumors

Background : Bone tumours are relatively uncommon. The precise incidence of specific bone tumours is not known, because many bone lesions are asymptomatic and are not biopsied. The initial work up and staging evaluation of a patient with a suspected bone tumour, particularly biopsy is a critical component of successful management. Aim :To assess the diagnostic accuracy of Fine needle aspirates and core needle biopsy of bone. The analysis compared with the accuracy according to anatomical location, size, type of lesion and histology. Materials and methods : 110 patients with bone tumours were referred to pathology department GMKMCH, Salem for diagnosis during the period from 2016 Nov to 2017 Nov. All had been examined by X-ray, CT, and (or) MRI, FNAB, CNB and excision biopsy with suspected local recurrence of primary malignant bone tumour (or) a metastatic lesion of a previously diagnosed malignancy were also included in this study. Results : Cytological diagnosis of 67/110 cases were compared with HPE after needle biopsy. Cytological diagnosis was correct for 76% of benign and 80% of malignant tumours. CNB was adequate in 96.7%. Sample for FNAC was obtained is 87.2%. The accuracy rate of open biopsy is almost 100%. Conclusion : The diagnostic accuracy of FNAC can be improved by the use of ancillary studies such as IHC, DNA cytometry, Karyotyping and medicular genetics in order to reduce the need for open biopsy of bone tumors. Keyword : Core needle biopsy (CNB), Fine needle aspiration cytology (FNAC) -------------------------------------------------------------------------------------------------------------------------------------Date of Submission: 25-12-2017 Date of acceptance:12-01-2018 -------------------------------------------------------------------------------------------------------------------------------------